| Place | Swimmer | Age | Club | Time | Std | Power pts |
|---|---|---|---|---|---|---|
| 2 | Ella Hafner | — | D2FHM | 5:00.91 | — | — |
| 3 | Evie Welser | 17 | D2PCEN | 5:10.46 | — | — |
| 4 | Skyler Jansen | 17 | MIBBA | 5:11.30 | — | 698 |
| 5 | Caroline Lee | — | D2FHM | 5:12.72 | — | — |
| 6 | Ava Smith | 16 | MIGKC | 5:14.13 | AAA | 679 |
| 7 | Danica Sadowski | 17 | MIGR | 5:15.10 | — | 673 |
| 9 | Annabelle Balazer | — | D2AASK | 5:15.55 | — | — |
| 10 | Samantha Memmer | 16 | MIBBD | 5:19.04 | AA | 648 |
| 11 | Maryn Smith | 17 | D2GPS | 5:20.24 | AA | 641 |
| 8 | Heidi Bryan | 17 | MIGPG | 5:20.98 | AA | 636 |
| 12 | Kamryn Eberhardt | — | D2ROAK | 5:23.04 | — | — |
| 13 | Sydney Meyer | — | D2FHM | 5:23.33 | — | — |
| 14 | Cailey Hard | — | D2GPN | 5:23.61 | — | — |
| 15 | Avery Russell | — | D2BCLK | 5:26.38 | — | — |
| 16 | Layla Stephens | — | D2BHS | 5:26.81 | — | — |
| — | Rebecca Turner | 16 | MIBHS | 5:27.39 | A | 600 |
| — | Meagan Larick | — | D2FARM | 5:27.60 | — | — |
| — | Rebekah Murillo | 16 | MIDCAC | 5:27.89 | A | 597 |
| — | Addison Dolliver | 17 | MIOLY | 5:29.16 | — | 590 |
| — | Madison Castron | 15 | MISLA | 5:30.18 | AA | 597 |
| — | Mira Tarraf | — | D2ROAK | 5:32.53 | — | — |
| — | Marta Jimenez-Pelay | — | D2BHGR | 5:32.80 | — | — |
| — | Bella Ruggirello | — | D2BHGR | 5:33.54 | — | — |
| — | Pepper Bray | 16 | D2SLYO | 5:36.27 | A | 554 |
| — | Isadora VanDuyn | 16 | MIWMS | 5:38.20 | A | 544 |
| — | Jessica Gleason | 17 | D2BERK | 5:41.46 | — | — |
| — | Mia Liddell | — | D2FHM | 5:42.38 | — | — |